生物单分子检测(单分子荧光成像与单分子力谱)   Single-molecule imaging of protein dynamics in living cells for signal transduction study: e.g. monitoring the protein diffusions to study their activation, internalization and recycling; measuring the intensities to study their stoichiometry. Results from monitoring the dynamic changes provide valuable information to enhance our understanding o...

纳米粒子与细胞的相互作用   With the ultrasensitive fluorescence microscopes and the integrated fluorescence/AFM system, nanomaterials are imaged and tracked in living cells to study their intracellular distribution, cell to cell transportation, and their biological effects.

纳米生物传感器   Development of “chemical-antibody”, the novel aptamer probes, to target tumor cells and disease-related proteins for the molecular elucidation of cancer; Development of aptamer-based nanobiosensors and fullerene based nanoprobes for diagnostic and therapeutic applications, including ultrasensitive protein/glucose sensors, multifunctional imagi...