（2）金属富勒烯调控巨噬细胞用于肿瘤免疫治疗：金属富勒烯氨基酸衍生物可以将肿瘤相关巨噬细胞从抑炎的M2型巨噬细胞调控到M1型巨噬细胞，通过分泌促炎因子以及激活肿瘤部位特异性免疫，实现了对于皮下乳腺癌的肿瘤免疫治疗。进一步通过分子生物学方法，初步揭示了金属富勒烯是通过激活了NF-γB和IRF5信号通路实现对于肿瘤相关巨噬细胞亚型的调控，相应成果发表在Nano lett. 2020, 20, 4487 杂志上。
（3）金属富勒烯在修复器官损伤中的应用：借助金属富勒烯高效清除自由基能力和器官靶向性，开发了基于金属富勒烯的器官损伤修复新方法。发现静脉注射水溶性金属富勒烯后，在单次及多次化疗损伤模型中都表现出了优异的骨髓和肝脏损伤修复效果，该方法大幅度降低了化疗副作用（ACS Appl. Mater. & Inter., 2018）。建立了基于金属富勒烯的肺纤维化治疗方法，通过雾化给药直接将羟基修饰的金属富勒烯递送至肺部组织，从而降低胶原蛋白沉积和肺部炎症，有效治疗肺纤维化（Nanomedicine-Nanotechnol., 2018）
（4）金属富勒烯在治疗代谢性疾病中的应用：长期致力于富勒烯及其衍生物的生物医学应用研究，在2019年首次报道了富勒烯通过改善胰岛素抵抗以及修复胰腺组织治疗II型糖尿病（ACS Nano 2019, 13, 8, 8597）；并证实富勒烯也可以有效的逆转肝脏脂肪变性，相应结果发表在Sci. Adv., 2020, 6, eabc1586杂志上，极大地推动了纳米技术在代谢性疾病治疗中的应用进程。
四、文章列表：
1. Chen Zhou, Mingming Zhen, * Meilan Yu, Xue Li, Tong Yu, Jingchao Liu, Wang Jia, Shuai Liu, Lei Li, Jie Li, Zihao Sun, Zhongpu Zhao, Xinyao Wang, Xiaoyan Zhang, Chunru Wang,* and Chunli Bai*.Gadofullerene inhibits the degradation of apolipoprotein B100 and boosts triglyceride transport for reversing hepatic steatosis. Sci. Adv., 2020, 6, eabc1586
2. Lei Li, Mingming Zhen,* Haoyu Wang, Zihao Sun, Wang Jia, Zhongpu Zhao, Chen Zhou, Shuai Liu, Chunru Wang,* and Chunli Bai. Functional Gadofullerene Nanoparticles Trigger Robust Cancer Immunotherapy Based on Rebuilding an Immunosuppressive Tumor Microenvironment. Nano Lett. 2020, 20, 4487-4496.
3. Wang Jia, Mingming Zhen,* Lei Li, Chen Zhou, Zihao Sun, Shuai Liu, Zhongpu Zhao, Jie Li, Chunru Wang* and Chunli Bai*. Gadofullerene nanoparticles for robust treatment of aplastic anemia induced by chemotherapy drugs. Theranostics, 2020, 10, 6886-6897.
4. Zhigao Lu, Wang Jia, Ruijun Deng, Yue Zhou, Xue Li, Tong Yu, Mingming Zhen* and Chunru Wang*, Light-assisted gadofullerene nanoparticles disrupt tumor vasculatures for potent melanoma treatment. J. Mater. Chem. B, 2020, 8, 2508.
5. Wang Jia, Ying Zhang, Mingming Zhen*, Jie Li, Tian Zhang, Chunying Shu, and Chunru Wang*. Gadofullerene Nanocrystals: A Robust, High-Efficiency Myelosuppressive Protector in Radiotherapy. ACS Appl. Bio Mater. 2020, 3, 450−457.
6. Tong Yu, Wang Jia, Mingming Zhen,* Yue Zhou, Jie Li and Chunru Wang*. Amino acid modified gadofullerene protects against insulin resistance induced by oxidative stress in 3T3-L1 adipocytes. J. Mater. Chem. B, 2020, 8, 7521-7527
7. Xue Li, Mingming Zhen*, Chen Zhou, Ruijun Deng, Tong Yu, Yingjie Wu, Chunying Shu, Chunru Wang*, Chunli Bai. Gadofullerene Nanoparticles Reverse Dysfunctions of Pancreas and Improve Hepatic Insulin Resistance for Type 2 Diabetes Mellitus Treatment. ACS Nano, 2019, 13, 8597.
8. Tong Yu, Mingming Zhen*, Jie Li, Yue Zhou, Hai-Jun Ma, Wang Jia, and Chun-Ru Wang*, Anti-apoptosis Effect of Amino Acid Modified Gadofullerene via Mitochondria Mediated Pathway. Dalton Transactions, 2019, 48, 7884.
9. Daiqin Chen, Yue Zhou, Dongzhi Yang, Mirong Guan, Mingming Zhen*, Weifei Lu, Marcian E. Van Dort, Brian D. Ross, Chunru Wang*, Chunying Shu, Hao Hong*. Positron Emission Tomography/Magnetic Resonance Imaging of Glioblastoma Using a Functionalized Gadofullerene Nanoparticle. ACS Applied Materials & Interfaces, 2019, 11, 21343
10. Xue Li, Mingming Zhen*, Ruijun Deng, Tong Yu, Jie Li, Ying Zhang, Toujun Zou, Yue Zhou, Zhigao Lu, Mirong Guan, Hui Xu, Chunying Shu and Chunru Wang*, RF-assisted gadofullerene nanoparticles induces rapid tumor vascular disruption by down-expression of tumor vascular endothelial, Biomaterials, 2018, 163, 142-153
11. Ruijun Deng, Yuqing Wang, Mingming Zhen*, Xue Li, Toujun Zou, Jie Li, Tong Yu, Yue Zhou, Zhigao Lu, Hui Xu, Ying Zhang, Chunying Shu and Chunru Wang*, Real-time monitoring of tumor vascular disruption induced by radiofrequency assisted gadofullerene, Sci. China Mater., 2018, 8,1101
12. Yue Zhou, Mingming Zhen*, Haijun Ma, Jie Li, Chunying Shu, Chunru Wang*, Inhalable gadofullerenol/[70] fullerenol as high-efficiency ROS scavengers for pulmonary fibrosis therapy, Nanomedicine-Nanotechnol., 2018, 4, 1361
13. Yue Zhou, Mingming Zhen*, Mi-Rong Guan, Liang Ma, Wei Li, Jia-Sheng Zheng, Chun-Ying Shu and Chun-Ru Wang*, Amino acid modified [70] fullerene derivatives with high radical scavenging activity as promising bodyguards for chemotherapy protection, Sci. Rep., 2018, 8, 16573
14. Yue Zhou, Ruijun Deng, Mingming Zhen*, Jie Li, Mirong Guan, Wang Jia, Xue Li, Ying Zhang, Tong Yu, Toujun Zou, Zhigao Lu, Jun Guo, Lei Sun, Chunying Shu, Chunru Wang*, Amino acid functionalized gadofullerene nanoparticles with superior antitumor activity via destruction of tumor vasculature in vivo, Biomaterials, 2017, 133, 107.
15. Yue Zhou, Jie Li, Haijun Ma, Mingming Zhen*, Jun Guo, Liping Wang, Li Jiang, Chunying Shu, Chunru Wang*, Biocompatible [60]/[70] fullerenols: potent defense against oxidative injury induced by reduplicative chemotherapy, Appl. Mater. Interfaces., 2017, 9, 35539.
16. Ying Zhang, Chunying Shu, Mingming Zhen*, Jie Li, Tong Yu, Wang Jia, Xue Li, Ruijun Deng, Yue Zhou, Chunru Wang*, A novel bone marrow targeted gadofullerene agent protect against oxidative injury in chemotherapy, Sci. China Mater., 2017, 60, 866.
17. Zhigao Lu, Ruijun Deng, Mingming Zhen,* Xue Li, Toujun Zou, Yue Zhou, Mirong Guan, Ying Zhang, Yuqing Wang, Tong Yu, Chunying Shu and Chunru Wang*, Size-tunable NaGdF4 nanoparticles as T2 contrast agents for high-field magnetic resonance imaging, RSC Adv., 2017, 7, 43125
18. Jie Li, Mirong Guan, Taishan Wang, Mingming Zhen*, Fuwen Zhao, Chunying Shu, Chunru Wang*, Gd@C82-(ethylenediamine)8 Nanoparticle: A New High-Efficiency Water-Soluble ROS Scavenger, Appl. Mater. Interfaces., 2016, 8, 25770
19. Mingming Zhen, Chunying Shu, Jie Li, Guoqiang Zhang, Taishan Wang, Yi Luo, Toujun Zou,Ruijun Deng, Fang Fang,Hao Lei, Chunru Wang* and Chunli Bai, A highly efficient and tumor vascular-targeting therapeutic technique with size-expansible gadofullerene nanocrystals, Sci. China Mater., 2015, 58,799
20. Mingming Zhen, Junpeng Zheng, Yifan Wang, Chunying Shu,* Fabao Gao, Jing Zou,* lmari Pyykkç, and Chunru Wang*, Multifunctional Nanoprobe for MRI/Optical Dual-Modality Imaging and Radical Scavenging, Chem. Eur. J. 2013, 19, 14675
21. Mingming Zhen, Junpeng Zheng, Lei Ye, Shumu Li, Chan Jin, Kai Li, Dong Qiu, Hongbin Han, Chunying Shu* Yongji Yang and Chunru Wang*, Maximizing the Relaxivity of Gd-Complex by Synergistic Effect of HSA and Carboxylfullerene, Appl. Mater. Interfaces., 2012, 4, 3724
五、主要论著：
王春儒，王太山，甄明明。金属富勒烯—从基础到应用，化学工业出版社，2018。
六、授权专利：
1. 王春儒，甄明明，舒春英，王太山，李杰，张国强，金属富勒烯单晶纳米颗粒在制备特异性肿瘤血管阻断剂中的应用，专利号：ZL 201410365005.4
2. 王春儒，甄明明，王太山，舒春英，张国强，邹头君，一种由纳米材料和外加辐射源组成的实现肿瘤血管阻断的肿瘤治疗药物，专利号：ZL 201410366213.6
3. 王春儒，甄明明，邹头君，舒春英，王太山，一种利用磁性微纳材料在交变磁场或射频驱动下破坏肿瘤血管的靶向抗癌药物，专利号：ZL 201410643728.6
4. 王春儒，甄明明，张莹，一种骨髓富集型微纳材料及其应用，专利号：ZL 201510671792.X
5. 王春儒，甄明明，张莹，预防和/或治疗骨髓抑制的富勒烯微纳材料及其应用，专利号：ZL 201610041914.1
6. 王春儒，甄明明，邹头君，舒春英，王太山，一种利用磁性微纳材料在交变磁场或射频驱动下破坏肿瘤血管的靶向抗癌药物，专利号：ZL 201410643728.6
7. 王春儒，甄明明，邓睿君，李雪，铁氧体纳米生物材料在制备靶向肿瘤诊疗药物中的应用，专利号：ZL 201510400432.6
8. 王春儒，邓睿君，甄明明，一种用于实时动态观测射频治疗中肿瘤微环境变化的装置，专利号：ZL 201710001410.1
9. 舒春英，甄明明，王春儒，肿瘤靶向性光敏剂及其制备方法与应用，专利号：ZL 201310291691.0
10. 舒春英，甄明明，王春儒，郑俊鹏，一种低场高弛豫率MRI造影剂及其制备方法，专利号：ZL 201110221384.6
七、基金项目：
1、 国家自然科学基金重大研发计划--培育项目《构筑可编程富勒烯纳米材料用于靶向抗肿瘤转移研究》，2021年01月-2023年12月，经费：80万，项目编号：92061123（主持）
2、国家自然科学基金青年科学基金项目《基于钆金属富勒烯的高效肿瘤诊疗探针的构筑及性质研究》，2016年01月-2018年12月），经费：20万，项目编号：51502301（主持）
3、 国家重大科研装备项目《金属富勒烯纳米肿瘤无创诊疗研究系统研制》，2016年02月-2019年12月，经费：6218万元，项目编号：ZDYZ2015-2 （项目骨干）
4、 中国科学院前沿局项目《高效金属富勒烯肿瘤血管阻断治疗技术物理机制研究》，2016年07月-2020年12月，经费：300万元，项目编号：QYZDJ-SSW-SLH025（项目骨干）
八、获奖情况：
2020年度中科院化学所优秀职工
2015年度中科院北京分院科技成果转化二等奖
2015年度中科院化学所青年科学奖优秀奖
2014年度中科院大学三好学生
2013年度中科院化学所所长奖学金
2012年度中科院化学所青年科学奖优秀奖
