徐 丽
副研究员
中科院化学所分子纳米实验室
化学所5#512
电话/传真:01062561679
1973年12月生于辽宁省。2006年7月于中科院动物所生殖生物学国家重点实验室获得生理学博士学位。 博士期间主要从事核酸疫苗的构建和生物学功能研究。现任中国科学院化学研究所分子纳米结构与纳米技术院重点实验室副研究员，近年来主要从事核酸实体的筛选和生物学功能研究，已经在复杂体系如细胞表面和单一体系如蛋白等体系筛选出特异性核酸适体，并对其生物学功能进行系统研究。
发表论文：
1. Wei Zhang, Jinghe Yuan, Yong Yang, Li Xu, Qiang Wang, Wei Zuo, Xiaohong Fang, Ye-Guang Chen. Monomeric type I and type III transforming growth factor-βreceptors and their dimerization revealed by single-molecule imaging. Cell Research,2010,20:1216-1223.
2. Kangmin He, Wangxi Luo, Yuliang Zhang, Fei Liu, Da Liu, Li Xu, Lei Qin, Chunyang Xiong, Zhizhen Lu, Xiaohong Fang,‡and Youyi Zhang. Intercellular Transportation of Quantum Dots Mediated by Membrane Nanotubes. ACS NANO, 2010, 4:3015-3022.
3. Zhao ZL, Xu L, Shi XL,Tan WH, Fang XH*,Dihua,SG. Recognition of subtype non-small cell lung cancer by DNA aptamer selected from living cells. Analyst, 2009, 134: 1808-1814.
4. Shi XL, Xu L,Yu JP, Fang XH*. Study of inhibition effect of herceptin on interaction between heregulin and ErbB receptors HER3/HER2 by single-molecule force spectroscopy. Experimental cell research, 2009, 315: 2847-2855.
5. Chen B, Liu QL, Zhang YL, Xu L, Fang XH*. Transmembrane Delivery of the Cell-Penetrating Peptide Conjugated Semiconductor Quantum Dots.. Langmuir 2008, 24: 11866-11871.
6. Xiao ZY, Zhang W, Yang Y, Xu L, Fang XH*. Single-molecule diffusion study of activated EGFR implicates its endocytic pathway. Biochemical and Biophysical Research Communications 2008, 369: 730-734.
7. Xu L, Shi SQ, Yang Y, Peng JP*. Four cDNA fragments from rabbit ZP3: their immunogenicity and effects on fertility. Fertility and Sterility, 2007, 87: 381-390.
8. Xu L, Shi SQ, Yang Y. Evaluation of the contraceptive*, Peng JP* potential of brZPCp vaccine in BALB/c mice: their safety and efficacy. DNA and Cell Biology 2006, 25: 87-94.
9. Shi SQ, Xu L, Zhao G, Yang Y, Peng JP*. Apoptosis and tumor inhibition induced by human chorionic gonadotropin beta in mouse breast carcinoma. Journal of Molecular Medicine, 2006, 84:933–941.
10. Chang JJ, Peng JP*, Yang Y, Wang JL, Xu L. Study on the Anti-fertility Effects of the Plasmid DNA Vaccine Expressing Partial brLDH-C4. Reproduction, 2006, 131: 183–192.
11. Li YC, Qin C, Liang GD, Shi SQ, Peng JP*, Xu L, Yang Y, Wang JL, Sun QH. The expression of membrane protein augments the specific responses induced by SARS-CoV nucleocapsid DNA immunization. Molecular Immunology, 2006, 43:1791-1798.
12. Shi SQ, Peng JP* Xu L, Yang Y, Chen Y. The mouse chorionic gonadotropin beta-subunit-like molecule produced by tumor cells elicits the swith of T-cell immunity response from TH2 to TH1 in mice immunized with DNA vaccine based on rhesus monkey homologous CG beta. Journal of Gene Medicine 2005, 7: 87-96.
专利：
方晓红，赵子龙，徐丽，上官棣华，谭蔚泓。用于不同亚型非小细胞肺癌分型的核酸适体及其筛选方法，专利号：ZL2009 1 0083075.X
